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Understanding RPL
Recurrent Pregnancy Loss (RPL), affecting approximately 1% to 2% of women, is defined as the loss of two or more clinical pregnancies.
While medically complex, the emotional toll is profound. It leaves couples seeking answers. Our comprehensive evaluation aims to identify underlying causes—whether genetic, anatomical, hormonal, or immunological—to provide a clear path forward and restore hope.
Common Causes
Identifying the root cause is the first step towards a successful pregnancy.
Genetic Factors
Chromosomal abnormalities in one or both parents can lead to non-viable pregnancies.
Anatomical Issues
Uterine abnormalities such as septums or fibroids can interfere with implantation.
Hormonal Imbalances
Issues like PCOS, thyroid disorders, or luteal phase defects can affect pregnancy maintenance.
Immunological Factors
Autoimmune conditions (like antiphospholipid syndrome) can lead to clot formation affecting the placenta.
Diagnostic
Evaluation
We offer a complete panel of tests to evaluate RPL, starting with karyotyping (chromosomal analysis) of both parents to rule out translocations. Further testing may include thrombophilia screening, hormonal profiles, and uterine imaging.
Our Approach
Comprehensive Karyotyping (Both Partners)
Thrombophilia Screening (APS Panel)
Hormonal Assays (Thyroid, Prolactin, etc)
Uterine Imaging (3D Ultrasound / Hysteroscopy)
Product of Conception (POC) Testing via NGS
Personalized
Care & Support
Dealing with RPL is emotionally taxing. Our team provides not just diagnostic answers but also compassionate genetic counseling to explain risks and discuss options like IVF with PGT-A or PGT-SR, which can significantly improve outcomes.
Treatment Options
Personalized care plans tailored to your specific diagnostic findings.
Hormonal Therapy
Addressing progesterone deficiencies, thyroid disorders, or other endocrine imbalances to support pregnancy maintenance.
Anticoagulation Therapy
Low-dose aspirin or heparin for women diagnosed with Antiphospholipid Antibody Syndrome (APS) or other clotting disorders.
Surgical Intervention
Correction of uterine anomalies such as septums, fibroids, or polyps through hysteroscopic procedures.
Genetic Counseling
Guidance for couples with chromosomal translocations, including options like IVF with PGT-A for embryo selection.
Lifestyle Modifications
Optimizing health through weight management, smoking cessation, and stress reduction to improve reproductive outcomes.
Frequently Asked Questions
Common queries about Understanding and managing RPL.
RPL is generally defined as the loss of two or more consecutive clinical pregnancies before 20 weeks of gestation. It affects approximately 1-2% of women.
No. While genetic causes (like chromosomal translocations) account for a significant portion, RPL can also be caused by anatomical issues, hormonal imbalances, autoimmune disorders, or lifestyle factors. In about 50% of cases, the cause remains unexplained, yet successful pregnancy is providing supportive care.
Evaluation typically includes parental karyotyping, thrombophilia screening, thyroid and prolactin testing, pelvic ultrasound/hysteroscopy for uterine anomalies, and sometimes sperm fragmentation analysis for the male partner.
Yes. Even after 3 consecutive losses, the chance of a successful future pregnancy is high (60-80%) with appropriate evaluation and supportive care.
We offer comprehensive genetic and diagnostic testing to identify the root cause. Our experts provide genetic counseling to explain your results and guide you toward the most effective treatment pathways.
